Complete Guide for Hydrophobic PTFE Syringe Filters

Hydrophobic PTFE syringe filters are used for filtration of organic solvents and gases, offering high chemical resistance and low extractables. They are commonly used in HPLC sample preparation, chemical analysis, and air filtration applications where aqueous compatibility is not required.

What Is a Hydrophobic PTFE Syringe Filter

A hydrophobic PTFE syringe filter is a membrane-based filtration device designed to remove particles from non-aqueous liquids and gases.

The PTFE membrane provides:

• strong resistance to solvents and chemicals
• low adsorption and extractables
• high filtration efficiency

Because the membrane is hydrophobic, it repels water unless pre-wetted, making it ideal for organic solvent filtration and gas applications.

How It Works

• The sample is drawn into a syringe
• The syringe filter is attached via Luer connection
• Pressure is applied manually
• The PTFE membrane removes particles and contaminants

The result is a clean and particle-free filtrate suitable for analytical instruments.

Typical Applications

HPLC and GC Sample Preparation

Removes particles before injection to protect analytical instruments.

Organic Solvent Filtration

Suitable for aggressive solvents, acids, and chemical mixtures.

Gas Filtration

Used to prevent moisture or contamination in air and gas lines.

Pharmaceutical and Chemical Analysis

Ensures sample purity and reproducibility.

How to Choose a PTFE Syringe Filter

Hydrophobic vs Hydrophilic

• Hydrophobic → organic solvents and gas
• Hydrophilic → aqueous or mixed solutions

Pore Size Selection

• 0.22 μm → fine filtration / sterilization
• 0.45 μm → general filtration
• >1 μm → coarse particle removal

Diameter Selection

Hydrophobic PTFE vs Other Membranes

Common Buyer Questions

When should I use hydrophobic PTFE filters?

When filtering organic solvents, gases, or aggressive chemicals.

Why is my filter clogging?

Possible reasons:

• high particle load
• incorrect pore size
• viscous sample

Using a pre-filter can improve performance.

Can PTFE filters be used for water?

Only after pre-wetting with alcohol, otherwise flow resistance will be high.

FAQ

What is a hydrophobic PTFE syringe filter used for?
Filtration of organic solvents, gases, and chemically aggressive samples.

What pore size should I choose?
0.22 μm for fine filtration, 0.45 μm for general use.

What is the main advantage of PTFE filters?
Excellent chemical resistance and low extractables.

Recommended Product

For reliable laboratory filtration, a hydrophobic PTFE syringe filter with wide chemical compatibility and stable flow rate is recommended.

View product details:
Hydrophobic PTFE Syringe Filters